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4ASA

The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90

Summary for 4ASA
Entry DOI10.2210/pdb4asa/pdb
Related1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZW9 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWS 2IWU 2IWX 2VW5 2VWC 2WEP 2WEQ 2WER 2XD6 2XX2 2XX4 2XX5 2YGA 2YGE 2YGF 4AS9 4ASB 4ASF 4ASG
DescriptorATP-DEPENDENT MOLECULAR CHAPERONE HSP82, [(3R,5S,6R,7R,12E)-5,11-dimethoxy-3,7,9,15,19-pentamethyl-6-oxidanyl-16,20,22-tris(oxidanylidene)-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate, CHLORIDE ION, ... (4 entities in total)
Functional Keywordschaperone, inhibition, ansamycin
Biological sourceSACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Cellular locationCytoplasm: P02829
Total number of polymer chains1
Total formula weight25508.57
Authors
Roe, S.M.,Prodromou, C. (deposition date: 2012-04-30, release date: 2013-04-03)
Primary citationKitson, R.R.A.,Chang, C.,Xiong, R.,Williams, H.E.L.,Davis, A.L.,Lewis, W.,Dehn, D.L.,Siegel, D.,Roe, S.M.,Prodromou, C.,Ross, D.,Moody, C.J.
Synthesis of 19-Substituted Geldanamycins with Altered Conformations and Their Binding to Heat Shock Protein Hsp90.
Nat.Chem., 5:307-, 2013
Cited by
PubMed: 23511419
DOI: 10.1038/NCHEM.1596
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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