1ZWH

Yeast Hsp82 in complex with the novel Hsp90 inhibitor Radester amine

Summary for 1ZWH

• Entry DOI: 10.2210/pdb1zwh/pdb
• Related: 1A4H 1BGQ 1OSF 1QY8 1U0Z 1YET
• Descriptor: ATP-dependent molecular chaperone HSP82, 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE (3 entities in total)
• Functional Keywords: hsp82, hsp90, grp94, htpg, chaperone, ligand, radicicol, geldanamycin
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Cytoplasm: P02829
• Total number of polymer chains: 1
• Total formula weight: 27442.58

Authors

Immormino, R.M.,Blagg, B.S.,Gewirth, D.T. (deposition date: 2005-06-03, release date: 2006-06-13, Last modification date: 2024-02-14)

• Primary citation: Immormino, R.M.,Blagg, B.S.,Gewirth, D.T.; Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design; To be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)