1BGQ
RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Summary for 1BGQ
Entry DOI | 10.2210/pdb1bgq/pdb |
Descriptor | HEAT SHOCK PROTEIN 90, RADICICOL (3 entities in total) |
Functional Keywords | chaperone, atp-binding, heat shock, inhibitor |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Cytoplasm: P02829 |
Total number of polymer chains | 1 |
Total formula weight | 25891.81 |
Authors | Roe, S.M.,Prodromou, C.,Pearl, L.H. (deposition date: 1998-05-29, release date: 1999-06-08, Last modification date: 2024-05-22) |
Primary citation | Roe, S.M.,Prodromou, C.,O'Brien, R.,Ladbury, J.E.,Piper, P.W.,Pearl, L.H. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J.Med.Chem., 42:260-266, 1999 Cited by PubMed: 9925731DOI: 10.1021/jm980403y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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