1BGQ

RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE

Summary for 1BGQ

DescriptorHEAT SHOCK PROTEIN 90, RADICICOL (3 entities in total)
Functional Keywordschaperone, atp-binding, heat shock, inhibitor
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Cellular locationCytoplasm P02829
Total number of polymer chains1
Total molecular weight25891.81
Authors
Roe, S.M.,Prodromou, C.,Pearl, L.H. (deposition date: 1998-05-29, release date: 1999-06-08, Last modification date: 2011-07-13)
Primary citation
Roe, S.M.,Prodromou, C.,O'Brien, R.,Ladbury, J.E.,Piper, P.W.,Pearl, L.H.
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
J.Med.Chem., 42:260-266, 1999
PubMed: 9925731 (PDB entries with the same primary citation)
DOI: 10.1021/jm980403y
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.245122.8%10.2%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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