4ASF

The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90

Summary for 4ASF

Entry DOI	10.2210/pdb4asf/pdb
Related	4AS9 4ASA 4ASB 4ASG
Descriptor	ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (8S,9R,13R,14S,16R)-21-(furan-2-yl)-13-hydroxy-8,14,19-trimethoxy-16-methyl-4,10,12-trimethylidene-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),18-dien-9-yl carbamate, NICKEL (II) ION, ... (4 entities in total)
Functional Keywords	inhibition, ansamycin, chaperone
Biological source	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Total number of polymer chains	1
Total formula weight	25676.17
Authors	Roe, S.M.,Prodromou, C. (deposition date: 2012-05-01, release date: 2013-04-03, Last modification date: 2019-01-30)
Primary citation	Kitson, R.R.,Chang, C.H.,Xiong, R.,Williams, H.E.,Davis, A.L.,Lewis, W.,Dehn, D.L.,Siegel, D.,Roe, S.M.,Prodromou, C.,Ross, D.,Moody, C.J. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem, 5:307-314, 2013 Cited by PubMed: 23511419 DOI: 10.1038/nchem.1596 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation