4AS9
The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90
Summary for 4AS9
Entry DOI | 10.2210/pdb4as9/pdb |
Related | 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZW9 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWS 2IWU 2IWX 2VW5 2VWC 2WEP 2WEQ 2WER 2XD6 2XX2 2XX4 2XX5 2YGA 2YGE 2YGF 4ASA 4ASB |
Descriptor | ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, [(3R,5S,6R,7R,10R,11S,12E)-5,11,21-trimethoxy-3,7,9,15,19-pentamethyl-6-oxidanyl-16,20,22-tris(oxidanylidene)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate (3 entities in total) |
Functional Keywords | chaperone, inhibitior, ansamycin |
Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
Total number of polymer chains | 1 |
Total formula weight | 25448.06 |
Authors | Roe, S.M.,Prodromou, C. (deposition date: 2012-04-30, release date: 2013-04-03, Last modification date: 2024-05-01) |
Primary citation | Kitson, R.R.,Chang, C.H.,Xiong, R.,Williams, H.E.,Davis, A.L.,Lewis, W.,Dehn, D.L.,Siegel, D.,Roe, S.M.,Prodromou, C.,Ross, D.,Moody, C.J. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem, 5:307-314, 2013 Cited by PubMed: 23511419DOI: 10.1038/nchem.1596 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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