2BRC

Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90.

Summary for 2BRC

• Entry DOI: 10.2210/pdb2brc/pdb
• Related: 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 2BRE
• Descriptor: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL (3 entities in total)
• Functional Keywords: atp-binding, chaperone, heat shock, inhibitor, multigene family, chaperone-complex
• Biological source: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• Cellular location: Cytoplasm : P02829
• Total number of polymer chains: 1
• Total formula weight: 24560.97

Authors

Roe, S.M.,Pearl, L.H.,Prodromou, C. (deposition date: 2005-05-04, release date: 2005-09-29, Last modification date: 2023-12-13)

• Primary citation: Cheung, K.M.,Matthews, T.P.,James, K.,Rowlands, M.G.,Boxall, K.J.,Sharp, S.Y.,Maloney, A.,Roe, S.M.,Prodromou, C.,Pearl, L.H.,Aherne, G.W.,McDonald, E.,Workman, P.; The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.; Bioorg. Med. Chem. Lett., 15:3338-3343, 2005; PubMed: 15955698; DOI: 10.1016/j.bmcl.2005.05.046

Experimental method

X-RAY DIFFRACTION (1.6 Å)