2CGF
A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Summary for 2CGF
Entry DOI | 10.2210/pdb2cgf/pdb |
Related | 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 2AKP 2BRC 2BRE 2CG9 2CGE |
Descriptor | ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE (3 entities in total) |
Functional Keywords | atp-binding, chaperone, heat shock, inhibitor, multigene family |
Biological source | SACCHAROMYCES CEREVISIAE (BAKERS YEAST) |
Cellular location | Cytoplasm: P02829 |
Total number of polymer chains | 1 |
Total formula weight | 25837.81 |
Authors | Roe, S.M.,Prodromou, C.,Pearl, L.H.,Moody, C.J. (deposition date: 2006-03-02, release date: 2006-11-29, Last modification date: 2024-05-01) |
Primary citation | Proisy, N.,Sharp, S.Y.,Boxall, K.,Connelly, S.,Roe, S.M.,Prodromou, C.,Slawin, A.M.Z.,Pearl, L.H.,Workman, P.,Moody, C.J. Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13:1203-, 2006 Cited by PubMed: 17114002DOI: 10.1016/J.CHEMBIOL.2006.09.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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