1ZW9
Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine
Summary for 1ZW9
Entry DOI | 10.2210/pdb1zw9/pdb |
Related | 1UY6 1UYF 1UYI |
Descriptor | HSP82, 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE (3 entities in total) |
Functional Keywords | hsp82, hsp90, grp94, htpg, chaperone, ligand, adenosine |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Cytoplasm: P02829 |
Total number of polymer chains | 1 |
Total formula weight | 27510.14 |
Authors | Immormino, R.M.,Gewirth, D.T.,Chiosis, G. (deposition date: 2005-06-03, release date: 2006-06-13, Last modification date: 2024-02-14) |
Primary citation | Immormino, R.M.,Gewirth, D.T.,Chiosis, G. Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design To be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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