2VW5

Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus Of Yeast Hsp90

Summary for 2VW5

Related1HK7 1A4H 1US7 2BRE 2CG9 1AH6 1USV 1BGQ 2IWS 1AMW 2BRC 1ZWH 1USU 1AH8 2CGF 2IWU 1AM1 2VLS 2IWX 2CGE 1ZW9 2AKP
DescriptorATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (4E,8S,9R,10E,12S,13R,14S,16R)-13,20-dihydroxy-14-methoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl carbamate, SULFATE ION, ... (4 entities in total)
Functional Keywordsatpase, cytoplasm, inhibitor, chaperone, atp-binding, stress response, nucleotide-binding
Biological sourceSACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Cellular locationCytoplasm P02829
Total number of polymer chains4
Total molecular weight99709.47
Authors
Roe, S.M.,Prodromou, C.,Pearl, L.H. (deposition date: 2008-06-16, release date: 2008-09-02, Last modification date: 2011-07-13)
Primary citation
Zhang, M.Q.,Gaisser, S.,Nur-E-Alam, M.,Sheehan, L.S.,Vousden, W.A.,Gaitatzis, N.,Peck, G.,Coates, N.J.,Moss, S.J.,Radzom, M.,Foster, T.A.,Sheridan, R.M.,Gregory, M.A.,Roe, S.M.,Prodromou, C.,Pearl, L.H.,Boyd, S.M.,Wilkinson, B.,Martin, C.J.
Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors.
J.Med.Chem., 51:5494-, 2008
PubMed: 18800759 (PDB entries with the same primary citation)
DOI: 10.1021/JM8006068
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.203501.9%6.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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