2XD6

Hsp90 complexed with a resorcylic acid macrolactone.

Summary for 2XD6

Entry DOI	10.2210/pdb2xd6/pdb
Related	1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZW9 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWS 2IWU 2IWX 2VLS 2VW5 2VWC 2WEP 2WEQ 2WER
Descriptor	ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-3,4,7,8,9,10,11,12-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-6-CARBALDEHYDE, GLYCEROL, ... (4 entities in total)
Functional Keywords	chaperone, inhibitor, atpase
Biological source	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Cellular location	Cytoplasm : P02829
Total number of polymer chains	1
Total formula weight	24943.75
Authors	Roe, S.M.,Prodromou, C.,Pearl, L.H.,Moody, C.J. (deposition date: 2010-04-29, release date: 2010-08-11, Last modification date: 2023-12-20)
Primary citation	Day, J.E.H.,Sharp, S.Y.,Rowlands, M.G.,Aherne, W.,Lewis, W.,Roe, S.M.,Prodromou, C.,Pearl, L.H.,Workman, P.,Moody, C.J. Inhibition of Hsp90 with Resorcylic Acid Macrolactones. Synthesis and Binding Studies. Chemistry, 16:10366-, 2010 Cited by PubMed: 20661961 DOI: 10.1002/CHEM.201001119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation