2XD6
Hsp90 complexed with a resorcylic acid macrolactone.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE XD6 A 1215 |
| Chain | Residue |
| A | ASN37 |
| A | THR171 |
| A | LEU173 |
| A | GOL1216 |
| A | HOH2058 |
| A | HOH2123 |
| A | HOH2124 |
| A | HOH2212 |
| A | HOH2213 |
| A | ASP40 |
| A | ALA41 |
| A | LYS44 |
| A | ASP79 |
| A | ILE82 |
| A | MET84 |
| A | ASN92 |
| A | PHE124 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1216 |
| Chain | Residue |
| A | ASN37 |
| A | ASP40 |
| A | GLY118 |
| A | GLY121 |
| A | XD61215 |
| A | HOH2061 |
| A | HOH2136 |
| A | HOH2214 |
| A | HOH2215 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1217 |
| Chain | Residue |
| A | LYS54 |
| A | GLN55 |
| A | THR58 |
| A | ASN141 |
| A | HOH2082 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1218 |
| Chain | Residue |
| A | ARG32 |
| A | GLU33 |
| A | SER36 |
| A | LEU50 |
| A | HOH2214 |
| A | HOH2216 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1219 |
| Chain | Residue |
| A | THR210 |
| A | HOH2103 |
| A | HOH2109 |
Functional Information from PROSITE/UniProt
| site_id | PS00298 |
| Number of Residues | 10 |
| Details | HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE |
| Chain | Residue | Details |
| A | TYR24-GLU33 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16625188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CG9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16625188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9230303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WEP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
