4AC4

CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-18

Summary for 4AC4

• Entry DOI: 10.2210/pdb4ac4/pdb
• Related: 1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G5U 2G9K 2GAB 2PAB 2ROX 2ROY 2TRH 2TRY 2WQA 4ABQ 4ABU 4ABV 4ABW 4AC2 5TTR
• Descriptor: TRANSTHYRETIN, 3-METHOXY-4-PHENOXYBENZOIC ACID (3 entities in total)
• Functional Keywords: transport protein, thyroxine transport protein, hormone, amyloidosis inhibition
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 28043.21

Authors

Tomar, D.,Khan, T.,Singh, R.R.,Mishra, S.,Gupta, S.,Surolia, A.,Salunke, D.M. (deposition date: 2011-12-13, release date: 2012-12-26, Last modification date: 2023-12-20)

Primary citation

Tomar, D.,Khan, T.,Singh, R.R.,Mishra, S.,Gupta, S.,Surolia, A.,Salunke, D.M.
Crystallographic Study of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity between Two Thyroxine Binding Sites.
Plos One, 7:43522-, 2012

PubMed Abstract: Transthyretin (TTR) is a homotetrameric serum and cerebrospinal fluid protein that transports thyroxine (T4) and retinol by binding to retinol binding protein. Rate-limiting tetramer dissociation and rapid monomer misfolding and disassembly of TTR lead to amyloid fibril formation in different tissues causing various amyloid diseases. Based on the current understanding of the pathogenesis of TTR amyloidosis, it is considered that the inhibition of amyloid fibril formation by stabilization of TTR in native tetrameric form is a viable approach for the treatment of TTR amyloidosis.

PubMed: 22973437
DOI: 10.1371/JOURNAL.PONE.0043522

Experimental method

X-RAY DIFFRACTION (1.8 Å)