1QWH

a covalent dimer of transthyretin that affects the amyloid pathway

Summary for 1QWH

Entry DOI	10.2210/pdb1qwh/pdb
Descriptor	Transthyretin (2 entities in total)
Functional Keywords	thyroid hormone, liver, plasma, cerebrospinal fluid, polyneuropathy, disease mutation, transport, thyroxine, binding protein, hormone-growth factor complex, hormone/growth factor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	25716.74
Authors	Foss, T.,Kelker, M.S.,Wilson, I.A. (deposition date: 2003-09-02, release date: 2004-09-14, Last modification date: 2023-08-16)
Primary citation	Foss, T.R.,Kelker, M.S.,Wiseman, R.L.,Wilson, I.A.,Kelly, J.W. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. J.Mol.Biol., 347:841-854, 2005 Cited by PubMed: 15769474 DOI: 10.1016/j.jmb.2005.01.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation