2G5U

Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl

Summary for 2G5U

• Entry DOI: 10.2210/pdb2g5u/pdb
• Descriptor: Transthyretin, 3,5,3',5'-TETRACHLORO-BIPHENYL-4,4'-DIOL (3 entities in total)
• Functional Keywords: ttr, amyloid, transthyretin, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28202.69

Authors

Palaninathan, S.K.,Smith, C.,Safe, S.H.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2006-02-23, release date: 2006-03-07, Last modification date: 2023-08-30)

• Primary citation: Purkey, H.E.,Palaninathan, S.K.,Kent, K.C.,Smith, C.,Safe, S.H.,Sacchettini, J.C.,Kelly, J.W.; Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity; Chem.Biol., 11:1719-1728, 2004; PubMed: 15610856; DOI: 10.1016/j.chembiol.2004.10.009

Experimental method

X-RAY DIFFRACTION (1.8 Å)