1GKO

An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured

Summary for 1GKO

Related1BM7 1BMZ 1BZ8 1BZD 1BZE 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1RLB 1THA 1THC 1TLM 1TSH 1TTA 1TTB 1TTC 1TTR 1TYR 2PAB 2ROX 2ROY 2TRH 2TRY 5TTR
DescriptorTRANSTHYRETIN (2 entities in total)
Functional Keywordstransport(thyroxine), transthyretin, ttr, mutant monomer transthyretin, mutant monomer ttr, amyloid forming protein, amyloid
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P02766
Total number of polymer chains4
Total molecular weight55117.68
Authors
Jiang, X.,Smith, C.S.,Petrassi, H.M.,Hammarstrom, P.,White, J.T.,Sacchettini, J.C.,Kelly, J.W. (deposition date: 2001-08-17, release date: 2001-11-28, Last modification date: 2011-07-13)
Primary citation
Jiang, X.,Smith, C.S.,Petrassi, H.M.,Hammarstrom, P.,White, J.T.,Sacchettini, J.C.,Kelly, J.W.
An Engineered Transthyretin Monomer that is Nonamyloidogenic, Unless It is Partially Denatured
Biochemistry, 40:11442-, 2001
PubMed: 11560492 (PDB entries with the same primary citation)
DOI: 10.1021/BI011194D
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers150.7%4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1gko
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Molmil generated image of 1gko
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Molmil generated image of 1gko
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 1gko
no rotation
Molmil generated image of 1gko
rotated about x axis by 90°
Molmil generated image of 1gko
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1gko.pdb2.gz [39.13 KB])
Coordinate files for Biological unit (1gko.pdb1.gz [38.28 KB])