2TRH

TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION

Summary for 2TRH

Entry DOI	10.2210/pdb2trh/pdb
Descriptor	TRANSTHYRETIN (2 entities in total)
Functional Keywords	albumin, transport, retinol-binding, vitamin a, amyloid, thyroid hormone, liver, plasma, cerebrospinal fluid, polyneuropathy, disease mutation, thyroxine, prealbumin
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	27662.82
Authors	Schormann, N.,Murrell, J.R.,Benson, M.D. (deposition date: 1996-10-16, release date: 1997-04-21, Last modification date: 2023-08-09)
Primary citation	Schormann, N.,Murrell, J.R.,Benson, M.D. Tertiary structures of amyloidogenic and non-amyloidogenic transthyretin variants: new model for amyloid fibril formation. Amyloid, 5:175-187, 1998 Cited by PubMed: 9818054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation