2F8I
Human transthyretin (TTR) complexed with Benzoxazole
Summary for 2F8I
| Entry DOI | 10.2210/pdb2f8i/pdb |
| Descriptor | Transthyretin, 2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACID (3 entities in total) |
| Functional Keywords | ttr; amyloid; transthyretin, hormone-growth factor complex, hormone/growth factor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28170.95 |
| Authors | Palaninathan, S.K.,Mohamedmohaideen, N.N.,Sacchettini, J.C.,Kelly, J.W. (deposition date: 2005-12-02, release date: 2005-12-20, Last modification date: 2023-08-30) |
| Primary citation | Razavi, H.,Palaninathan, S.K.,Powers, E.T.,Wiseman, R.L.,Purkey, H.E.,Mohamedmohaideen, N.N.,Deechongkit, S.,Chiang, K.P.,Dendle, M.T.,Sacchettini, J.C.,Kelly, J.W. Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action Angew.Chem.Int.Ed.Engl., 42:2758-2761, 2003 Cited by PubMed: 12820260DOI: 10.1002/anie.200351179 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.541 Å) |
Structure validation
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