2YIS
triazolopyridine inhibitors of p38 kinase.
Summary for 2YIS
Entry DOI | 10.2210/pdb2yis/pdb |
Related | 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2I0H 2Y8O 2YIW 2YIX |
Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 14, 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total) |
Functional Keywords | transferase, inhibitor sbdd kinase, cell cycle |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42169.51 |
Authors | Millan, D.S.,Anderson, M.,Bazin, R.,Bunnage, M.E.,Burrows, J.L.,Butcher, K.J.,Dodd, P.G.,Evans, T.J.,Fairman, D.A.,Hughes, S.J.,Irving, S.L.,Kilty, I.C.,Lemaitre, A.,Lewthwaite, R.A.,Mahnke, A.,Mathais, J.P.,Philip, J.,Phillips, C.,Smith, R.T.,Stefaniack, M.H.,Yeadon, M. (deposition date: 2011-05-16, release date: 2011-11-30, Last modification date: 2024-05-08) |
Primary citation | Millan, D.S.,Bunnage, M.E.,Burrows, J.L.,Butcher, K.J.,Dodd, P.G.,Evans, T.J.,Fairman, D.A.,Hughes, S.J.,Kilty, I.C.,Lemaitre, A.,Lewthwaite, R.A.,Mahnke, A.,Mathias, J.P.,Philip, J.,Smith, R.T.,Stefaniak, M.H.,Yeadon, M.,Phillips, C. Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease. J.Med.Chem., 54:7797-, 2011 Cited by PubMed: 21888439DOI: 10.1021/JM200677B PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)