2YIS
triazolopyridine inhibitors of p38 kinase.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MITOGEN-ACTIVATED PROTEIN KINASE 14 | polymer | 359 | 41212.0 | 1 | UniProt (Q16539) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | MAP KINASE 14, MAPK 14, CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG-BINDING PROTEIN, CSAID-BINDING PROTEIN, CSBP, MAP KINASE MXI2, MAX-INTERACTING PROTEIN 2, P38 KINASE, MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA, MAP KINASE P38 ALPHA, SAPK2A |
| 2 | B (A) | 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea | non-polymer | 700.3 | 1 | Chemie (YIS) | |||
| 3 | C (A) | 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine | non-polymer | 257.2 | 1 | Chemie (I46) | |||
| 4 | D (A) | water | water | 18.0 | 247 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41212.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 957.5 | |
| All* | Total formula weight | 42169.5 |
