1BMK

THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655

Summary for 1BMK

DescriptorPROTEIN (MAP KINASE P38), 4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE (3 entities in total)
Functional Keywordstransferase, inhibitors, map kinase, serine/ threonine-protein kinase, p38
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  Q16539
Total number of polymer chains1
Total molecular weight43687.65
Authors
Wang, Z.,Canagarajah, B.,Boehm, J.C.,Kassis, S.,Cobb, M.H.,Young, P.R.,Abdel-Meguid, S.,Adams, J.L.,Goldsmith, E.J. (deposition date: 1998-07-23, release date: 1999-07-23, Last modification date: 2017-02-01)
Primary citation
Wang, Z.,Canagarajah, B.J.,Boehm, J.C.,Kassisa, S.,Cobb, M.H.,Young, P.R.,Abdel-Meguid, S.,Adams, J.L.,Goldsmith, E.J.
Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6:1117-1128, 1998
PubMed: 9753691 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(98)00113-0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers162.6%11.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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