1YQJ

Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor

Summary for 1YQJ

Entry DOI	10.2210/pdb1yqj/pdb
Descriptor	Mitogen-activated protein kinase 14, SULFATE ION, 6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE, ... (4 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	42552.57
Authors	Tamayo, N.,Liao, H.,Goldberg, M.,Syed, R.,Li, V.,Powers, D.,Tudor, Y.,Yu, V.,Wong, M.L.,Henkle, B.,Middelton, S.,Harvey, T.,Jang, G.,Hungate, R.,Dominguez, C. (deposition date: 2005-02-01, release date: 2005-04-26, Last modification date: 2023-08-23)
Primary citation	Tamayo, N.,Liao, L.,Goldberg, M.,Powers, D.,Tudor, Y.Y.,Yu, V.,Wong, L.M.,Henkle, B.,Middleton, S.,Syed, R.,Harvey, T.,Jang, G.,Hungate, R.,Dominguez, C. Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 15:2409-2413, 2005 Cited by PubMed: 15837335 DOI: 10.1016/j.bmcl.2005.02.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation