1YQJ
Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 366 | 41998.9 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | Mitogen-activated protein kinase p38alpha, MAP kinase p38alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (A) | 6((S)-3-BENZYLPIPERAZIN-1-YL)-3-(NAPHTHALEN-2-YL)-4-(PYRIDIN-4-YL)PYRAZINE | non-polymer | 457.6 | 1 | Chemie (6NP) | |||
| 4 | D (A) | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A: 2 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | cloning artifact |
| Ser -4 | - | cloning artifact |
| His -3 | - | cloning artifact |
| Met -2 | - | cloning artifact |
| Leu -1 | - | cloning artifact |
| Glu 0 | - | cloning artifact |
| Met 1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41998.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 553.6 | |
| All* | Total formula weight | 42552.6 |
