1OUK

The structure of p38 alpha in complex with a pyridinylimidazole inhibitor

Summary for 1OUK
Related1M7Q
DescriptorMitogen-activated protein kinase 14, SULFATE ION, 4-[5-[2-(1-PHENYL-ETHYLAMINO)-PYRIMIDIN-4-YL]-1-METHYL-4-(3-TRIFLUOROMETHYLPHENYL)-1H-IMIDAZOL-2-YL]-PIPERIDINE, ... (4 entities in total)
Functional Keywordsmap kinase, hydrophobic pocket, kinase domain, atp binding domain, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : Q16539
Total number of polymer chains1
Total formula weight42601.57
Authors
Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G. (deposition date: 2003-03-24, release date: 2003-09-02, Last modification date: 2017-10-11)
Primary citationBecker, J.W.,Cameron, P.M.,Fitzgerald, C.E.,O'Keefe, S.J.,Patel, S.B.,Pikounis, V.B.,Scapin, G.,Zaller, D.
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
Nat.Struct.Biol., 10:764-769, 2003
PubMed: 12897767
DOI: 110.1038/nsb949
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation
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178938

PDB entries from 2021-06-16