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1OUK

The structure of p38 alpha in complex with a pyridinylimidazole inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMitogen-activated protein kinase 14polymer36641998.91UniProt (Q16539)
Pfam (PF00069)
In PDB
Homo sapiens (human)Mitogen-activated protein kinase p38, MAP kinase p38, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2
2ASULFATE IONnon-polymer96.11Chemie (SO4)
3A4-[5-[2-(1-PHENYL-ETHYLAMINO)-PYRIMIDIN-4-YL]-1-METHYL-4-(3-TRIFLUOROMETHYLPHENYL)-1H-IMIDAZOL-2-YL]-PIPERIDINEnon-polymer506.61Chemie (084)
4waterwater18.0138Chemie (HOH)
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
PDBExternal DatabaseDetails
Gly -5-cloning artifact
Ser -4-cloning artifact
His -3-cloning artifact
Met -2-cloning artifact
Leu -1-cloning artifact
Glu 0-cloning artifact
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight41998.9
Non-Polymers*Number of molecules2
Total formula weight602.6
All*Total formula weight42601.6
*Water molecules are not included.

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PDB entries from 2024-03-27

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