2YIS

triazolopyridine inhibitors of p38 kinase.

2YIS の概要

• エントリーDOI: 10.2210/pdb2yis/pdb
• 関連するPDBエントリー: 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2I0H 2Y8O 2YIW 2YIX
• 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total)
• 機能のキーワード: transferase, inhibitor sbdd kinase, cell cycle
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42169.51

構造登録者

Millan, D.S.,Anderson, M.,Bazin, R.,Bunnage, M.E.,Burrows, J.L.,Butcher, K.J.,Dodd, P.G.,Evans, T.J.,Fairman, D.A.,Hughes, S.J.,Irving, S.L.,Kilty, I.C.,Lemaitre, A.,Lewthwaite, R.A.,Mahnke, A.,Mathais, J.P.,Philip, J.,Phillips, C.,Smith, R.T.,Stefaniack, M.H.,Yeadon, M. (登録日: 2011-05-16, 公開日: 2011-11-30)

• 主引用文献: Millan, D.S.,Bunnage, M.E.,Burrows, J.L.,Butcher, K.J.,Dodd, P.G.,Evans, T.J.,Fairman, D.A.,Hughes, S.J.,Kilty, I.C.,Lemaitre, A.,Lewthwaite, R.A.,Mahnke, A.,Mathias, J.P.,Philip, J.,Smith, R.T.,Stefaniak, M.H.,Yeadon, M.,Phillips, C.; Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease.; J.Med.Chem., 54:7797-, 2011; PubMed: 21888439; DOI: 10.1021/JM200677B

実験手法

X-RAY DIFFRACTION (2 Å)