2W3B

HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)

2W3B の概要

• エントリーDOI: 10.2210/pdb2w3b/pdb
• 関連するPDBエントリー: 1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3M
• 分子名称: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, ... (6 entities in total)
• 機能のキーワード: nonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46150.14

構造登録者

Leung, A.K.W.,Reynolds, R.C.,Borhani, D.W. (登録日: 2008-11-11, 公開日: 2009-11-17, 最終更新日: 2019-05-08)

• 主引用文献: Leung, A.K.W.,Ross, L.J.,Zywno-Van Ginkel, S.,Reynolds, R.C.,Seitz, L.E.,Pathak, V.,Barrow, W.W.,White, E.L.,Suling, W.J.,Piper, J.R.,Borhani, D.W.; Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate; To be Published,

実験手法

X-RAY DIFFRACTION (1.27 Å)