2DHF

CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE

Summary for 2DHF

DescriptorDIHYDROFOLATE REDUCTASE, 5-DEAZAFOLIC ACID (3 entities in total)
Functional Keywordsoxido-reductase, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion  P00374
Total number of polymer chains2
Total molecular weight43579.87
Authors
Davies /II, J.F.,Kraut, J. (deposition date: 1989-10-25, release date: 1990-07-15, Last modification date: 2017-11-29)
Primary citation
Davies 2nd., J.F.,Delcamp, T.J.,Prendergast, N.J.,Ashford, V.A.,Freisheim, J.H.,Kraut, J.
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.
Biochemistry, 29:9467-9479, 1990
PubMed: 2248959 (PDB entries with the same primary citation)
DOI: 10.1021/bi00492a021
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers451.7%22.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution