1MVS

Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase

Summary for 1MVS

Entry DOI	10.2210/pdb1mvs/pdb
Related	1LY3 1LY4 1MVT
Descriptor	Dihydrofolate Reductase, SULFATE ION, 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total)
Functional Keywords	dihydrofolate reductase, human dhfr, antifolate, n9-c10 reverse bridge pyrolopyrimidine, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	1
Total formula weight	22043.26
Authors	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.A.,Gangjee, A. (deposition date: 2002-09-26, release date: 2003-04-01, Last modification date: 2024-02-14)
Primary citation	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Gangjee, A. Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 59:654-661, 2003 Cited by PubMed: 12657784 DOI: 10.1107/S0907444903001951 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation