1MVS

Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase

Summary for 1MVS
Related1LY3 1LY4 1MVT
DescriptorDihydrofolate Reductase, SULFATE ION, 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total)
Functional Keywordsdihydrofolate reductase, human dhfr, antifolate, n9-c10 reverse bridge pyrolopyrimidine, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion : P00374
Total number of polymer chains1
Total formula weight22043.26
Authors
Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.A.,Gangjee, A. (deposition date: 2002-09-26, release date: 2003-04-01, Last modification date: 2018-02-14)
Primary citationCody, V.,Galitsky, N.,Gangjee, A.,Luft, J.R.,Pangborn, W.
Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 59:654-661, 2003
PubMed: 12657784
DOI: 110.1107/S0907444903001951
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation
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PDB entries from 2021-06-16