1MVS
Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydrofolate Reductase | polymer | 187 | 21480.7 | 1 | UniProt (P00374) Pfam (PF00186) In PDB | Homo sapiens (human) | |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | A | 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE | non-polymer | 370.4 | 1 | Chemie (DTM) | |||
| 4 | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21480.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 562.5 | |
| All* | Total formula weight | 22043.3 |
