1LY4

Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase

Summary for 1LY4

Entry DOI	10.2210/pdb1ly4/pdb
Related	1CD2 1D8R 1DAJ 1LY3
Descriptor	DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total)
Functional Keywords	pcdhfr, n9-c10 reversed bridge pyridopyrimidine antifolate, oxidoreductase
Biological source	Pneumocystis carinii
Total number of polymer chains	1
Total formula weight	25002.32
Authors	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Queener, S.F.,Gangjee, A. (deposition date: 2002-06-06, release date: 2002-08-28, Last modification date: 2024-02-14)
Primary citation	Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Queener, S.F.,Gangjee, A. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr.,Sect.D, 58:1393-1399, 2002 Cited by PubMed: 12198294 DOI: 10.1107/S0907444902010442 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation