1MVT
Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
Summary for 1MVT
Entry DOI | 10.2210/pdb1mvt/pdb |
Related | 1mvs |
Descriptor | Dihydrofolate Reductase, SULFATE ION, 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total) |
Functional Keywords | dihydrofolate reductase, human dhfr, antifolate, n9-c10 reverse bridge pyrolopyrimidine, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion : P00374 |
Total number of polymer chains | 1 |
Total formula weight | 22043.26 |
Authors | Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.A.,Gangjee, A. (deposition date: 2002-09-26, release date: 2003-04-01, Last modification date: 2024-02-14) |
Primary citation | Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Gangjee, A. Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 59:654-661, 2003 Cited by PubMed: 12657784DOI: 10.1107/S0907444903001951 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report