Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1KMV

HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE

Summary for 1KMV
Entry DOI10.2210/pdb1kmv/pdb
Related1KMS
DescriptorDIHYDROFOLATE REDUCTASE, SULFATE ION, (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, ... (6 entities in total)
Functional Keywordsoxidoreductase, antiparasitic drugs, reductase, lipophilic antifolates
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight22606.52
Authors
Klon, A.E.,Heroux, A.,Ross, L.J.,Pathak, V.,Johnson, C.A.,Piper, J.R.,Borhani, D.W. (deposition date: 2001-12-17, release date: 2002-07-10, Last modification date: 2024-02-14)
Primary citationKlon, A.E.,Heroux, A.,Ross, L.J.,Pathak, V.,Johnson, C.A.,Piper, J.R.,Borhani, D.W.
Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.
J.Mol.Biol., 320:677-693, 2002
Cited by
PubMed: 12096917
DOI: 10.1016/S0022-2836(02)00469-2
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.05 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon