1S3V
Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
Summary for 1S3V
Entry DOI | 10.2210/pdb1s3v/pdb |
Descriptor | Dihydrofolate reductase, SULFATE ION, (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, ... (4 entities in total) |
Functional Keywords | dihydrofolate reductase, inhibitor, stereochemistry, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 21917.12 |
Authors | Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. (deposition date: 2004-01-14, release date: 2004-03-30, Last modification date: 2011-07-13) |
Primary citation | Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60:646-655, 2004 Cited by PubMed: 15039552DOI: 10.1107/S0907444904002094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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