1OHJ

HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM

Summary for 1OHJ

DescriptorDIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID, ... (4 entities in total)
Functional Keywordsoxidoreductase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight22668.51
Authors
Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W. (deposition date: 1997-09-17, release date: 1998-04-29, Last modification date: 2011-07-13)
Primary citation
Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Blakley, R.L.
Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
Biochemistry, 36:13897-13903, 1997
PubMed: 9374868 (PDB entries with the same primary citation)
DOI: 10.1021/bi971711l
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers382.2%13.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution