1U72

Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

Summary for 1U72

DescriptorDihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total)
Functional Keywordswild type humand dhfr, oxidoreductase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight22549.39
Authors
Cody, V. (deposition date: 2004-08-02, release date: 2005-02-01, Last modification date: 2011-07-13)
Primary citation
Cody, V.,Luft, J.R.,Pangborn, W.
Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
Acta Crystallogr.,Sect.D, 61:147-155, 2005
PubMed: 15681865 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444904030422
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers26014.9%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution