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1U72

Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

Summary for 1U72
Entry DOI10.2210/pdb1u72/pdb
DescriptorDihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total)
Functional Keywordswild type humand dhfr, oxidoreductase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight22549.38
Authors
Cody, V. (deposition date: 2004-08-02, release date: 2005-02-01, Last modification date: 2024-02-14)
Primary citationCody, V.,Luft, J.R.,Pangborn, W.
Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
Acta Crystallogr.,Sect.D, 61:147-155, 2005
Cited by
PubMed: 15681865
DOI: 10.1107/S0907444904030422
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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