Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

Summary for 1U72

DescriptorDihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total)
Functional Keywordswild type humand dhfr, oxidoreductase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight22549.39
Cody, V. (deposition date: 2004-08-02, release date: 2005-02-01, Last modification date: 2011-07-13)
Primary citation
Cody, V.,Luft, J.R.,Pangborn, W.
Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
Acta Crystallogr.,Sect.D, 61:147-155, 2005
PubMed: 15681865 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444904030422
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers260 14.9%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21