1S3W

Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry

Summary for 1S3W

Entry DOI	10.2210/pdb1s3w/pdb
Descriptor	Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, ... (4 entities in total)
Functional Keywords	dihydrofolate reductase, inhibitor complex, stereochemistry, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22400.41
Authors	Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. (deposition date: 2004-01-14, release date: 2004-03-30, Last modification date: 2024-02-14)
Primary citation	Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.,Queener, S.F. Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60:646-655, 2004 Cited by PubMed: 15039552 DOI: 10.1107/S0907444904002094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation