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1PD8

Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase

Summary for 1PD8
Entry DOI10.2210/pdb1pd8/pdb
Related1PD9 1PDB
DescriptorDihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total)
Functional Keywordshuman dihydrofolate reductase inhibitor complex, oxidoreductase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight22479.38
Authors
Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A. (deposition date: 2003-05-19, release date: 2003-12-09, Last modification date: 2023-08-16)
Primary citationCody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.
Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 59:1603-1609, 2003
Cited by
PubMed: 12925791
DOI: 10.1107/S0907444903014963
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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