2VUK

Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083

Summary for 2VUK

• Entry DOI: 10.2210/pdb2vuk/pdb
• Related: 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2FEJ 2GS0 2H1L 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 3SAK
• Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION, 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine, ... (4 entities in total)
• Functional Keywords: metal binding, phosphoprotein, ubl conjugation, activator, cell cycle, acetylation, methylation, zinc, cancer, nucleus, apoptosis, cytoplasm, tumor suppressor, virtual screening, second-site suppressor mutation, covalent protein-rna linkage, small-molecule drug, alternative splicing, p53 dna- binding domain, transcription regulation, nuclear protein, surface crevice, disease mutation, protein stabilization, host-virus interaction, li-fraumeni syndrome, endoplasmic reticulum, metal-binding, anti-oncogene, transcription, superstable mutant, dna-binding protein, dna binding, dna-binding, polymorphism, glycoprotein
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 49430.77

Authors

Joerger, A.C.,Boeckler, F.M.,Fersht, A.R. (deposition date: 2008-05-26, release date: 2008-07-22, Last modification date: 2023-12-13)

• Primary citation: Boeckler, F.M.,Joerger, A.C.,Jaggi, G.,Rutherford, T.J.,Veprintsev, D.B.,Fersht, A.R.; Targeted Rescue of a Destabilized Mutant of P53 by an in Silico Screened Drug.; Proc.Natl.Acad.Sci.USA, 105:10360-, 2008; PubMed: 18650397; DOI: 10.1073/PNAS.0805326105

Experimental method

X-RAY DIFFRACTION (1.5 Å)