2VUK
Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CELLULAR TUMOR ANTIGEN P53 | polymer | 219 | 24530.8 | 2 | UniProt (P04637) Pfam (PF00870) | HOMO SAPIENS (HUMAN) | TUMOR SUPPRESSOR P53, PHOSPHOPROTEIN P53, ANTIGEN NY-CO-13, P53 |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D (B) | 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine | non-polymer | 238.3 | 1 | Chemie (P83) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 434 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Leu 133 | Met 133 | engineered mutation |
| Ala 203 | Val 203 | engineered mutation |
| Cys 220 | Tyr 220 | engineered mutation |
| Tyr 239 | Asn 239 | engineered mutation |
| Asp 268 | Asn 268 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49061.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 369.1 | |
| All* | Total formula weight | 49430.8 |
