1UOL
Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
Summary for 1UOL
Entry DOI | 10.2210/pdb1uol/pdb |
Related | 1A1U 1AIE 1DT7 1GZH 1H26 1HS5 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1YCQ 1YCR 1YCS 3SAK |
Descriptor | CELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total) |
Functional Keywords | dna-binding protein, p53, dna-binding domain, tumor suppressor, second-site suppressor mutation, superstable mutant, apoptosis, transcription regulation, dna binding protein |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 2 |
Total formula weight | 49312.50 |
Authors | Joerger, A.C.,Allen, M.D.,Fersht, A.R. (deposition date: 2003-09-19, release date: 2003-10-16, Last modification date: 2024-05-08) |
Primary citation | Joerger, A.C.,Allen, M.D.,Fersht, A.R. Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations J.Biol.Chem., 279:1291-, 2004 Cited by PubMed: 14534297DOI: 10.1074/JBC.M309732200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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