2JDO

STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE

Summary for 2JDO

• Entry DOI: 10.2210/pdb2jdo/pdb
• Related: 1GNG 1GZK 1GZN 1GZO 1H8F 1I09 1J1B 1J1C 1MRV 1MRY 1O6K 1O6L 1O9U 1P6S 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDR 2JDS 2JDT 2JDV
• Descriptor: RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE, ... (5 entities in total)
• Functional Keywords: wnt signaling pathway, serine/threonine-protein kinase, kinase, transferase, atp-binding, phosphorylation, nucleotide-binding, alternative splicing
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P49841
• Total number of polymer chains: 2
• Total formula weight: 41465.60

Authors

Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,Mchardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D. (deposition date: 2007-01-11, release date: 2007-02-13, Last modification date: 2011-07-13)

• Primary citation: Davies, T.G.,Verdonk, M.L.,Graham, B.,Saalau-Bethell, S.,Hamlett, C.C.F.,Mchardy, T.,Collins, I.,Garrett, M.D.,Workman, P.,Woodhead, S.J.,Jhoti, H.,Barford, D.; A Structural Comparison of Inhibitor Binding to Pkb, Pka and Pka-Pkb Chimera; J.Mol.Biol., 367:882-, 2007; PubMed: 17275837; DOI: 10.1016/J.JMB.2007.01.004

Experimental method

X-RAY DIFFRACTION (1.8 Å)