2J3Q

Torpedo acetylcholinesterase complexed with fluorophore thioflavin T

Summary for 2J3Q

Entry DOI	10.2210/pdb2j3q/pdb
Related	1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1H23 1HBJ 1JGA 1JGB 1JJB 1OCE 1ODC 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1U65 1UT6 1VOT 1VXO 1VXR 1W4L 1W6R 1W75 1W76 1ZGB 1ZGC 2ACE 2ACK 2C4H 2C58 2C5F 2C5G 2CEK 2CKM 2CMF 2DFP 2J3D 3ACE 4ACE
Descriptor	ACETYLCHOLINESTERASE, 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	serine esterase, alternative splicing, lipoprotein, glycoprotein, torpedo ache, neurotransmitter degradation, anticancer prodrug cpt- 11, synapse, membrane, hydrolase, gpi-anchor
Biological source	TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
Total number of polymer chains	1
Total formula weight	62322.71
Authors	Harel, M.,Cusack, B.,Johnson, J.L.,Silman, I.,Sussman, J.L.,Rosenberry, T.L. (deposition date: 2006-08-23, release date: 2007-09-04, Last modification date: 2023-12-13)
Primary citation	Harel, M.,Sonoda, L.K.,Silman, I.,Sussman, J.L.,Rosenberry, T.L. Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. J. Am. Chem. Soc., 130:7856-7861, 2008 Cited by PubMed: 18512913 DOI: 10.1021/ja7109822 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation