2ACE

NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA

Replaces:  1ACE

Summary for 2ACE

DescriptorACETYLCHOLINESTERASE, ACETYLCHOLINE (3 entities in total)
Functional Keywordsserine hydrolase, neurotransmitter cleavage, catalytic triad, alpha/beta hydrolase
Biological sourceTorpedo californica (Pacific electric ray)
Cellular locationIsoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein P04058
Total number of polymer chains1
Total molecular weight60882.72
Authors
Harel, M.,Raves, M.L.,Silman, I.,Sussman, J.L. (deposition date: 1996-06-23, release date: 1996-11-08, Last modification date: 2016-06-22)
Primary citation
Raves, M.L.,Harel, M.,Pang, Y.-P.,Silman, I.,Kozikowski, A.P.,Sussman, J.L.
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nat.Struct.Biol., 4:57-63, 1997
PubMed: 8989325 (PDB entries with the same primary citation)
DOI: 10.1038/nsb0197-57
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.231150.4%5.7%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2ace
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Molmil generated image of 2ace
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Molmil generated image of 2ace
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More Biological unit images

Molmil generated image of 2ace
no rotation
Molmil generated image of 2ace
rotated about x axis by 90°
Molmil generated image of 2ace
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2ace.pdb1.gz [175.95 KB])
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