2ACE

NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA

Replaces:  1ACE
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Functional Information from GO Data

ChainGOidnamespacecontents
A0031225cellular_componentanchored component of membrane
A0030054cellular_componentcell junction
A0005886cellular_componentplasma membrane
A0043083cellular_componentsynaptic cleft
A0003990molecular_functionacetylcholinesterase activity
A0001507biological_processacetylcholine catabolic process in synaptic cleft
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
CAT3CATALYTIC TRIAD.
ChainResidue
ASER200
AGLU327
AHIS440

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ACH_2ace_A_99814ACETYLCHOLINE binding site
ChainResidueligand
ATRP84ACH: ACETYLCHOLINE
AGLY117-GLY119ACH: ACETYLCHOLINE
AGLU199-ALA201ACH: ACETYLCHOLINE
ATRP233ACH: ACETYLCHOLINE
APHE288ACH: ACETYLCHOLINE
APHE290ACH: ACETYLCHOLINE
APHE330-PHE331ACH: ACETYLCHOLINE
AHIS440-GLY441ACH: ACETYLCHOLINE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0012216Carboxylesterases type-B serine active site. F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
ChainResidueDetails
APHE187-GLY202

PS0094111Carboxylesterases type-B signature 2. [EDA]-[DG]-C-L-[YTF]-[LIVT]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
ChainResidueDetails
AGLU92-PRO102

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12Charge relay system.
ChainResidueDetails
AGLU327
AHIS440

SWS_FT_FI21Acyl-ester intermediate.
ChainResidueDetails
ASER200

CSA13a catalytic site defined by CSA, PubMed 8989325
ChainResidueDetails
ASER200
AHIS440
AGLU327

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA13a catalytic site defined by CSA, PubMed 8989325
ChainResidueDetails
ASER200
AHIS440
AGLU327