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1VXO

METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)

Summary for 1VXO
Entry DOI10.2210/pdb1vxo/pdb
DescriptorPROTEIN (ACETYLCHOLINESTERASE), 2-acetamido-2-deoxy-beta-D-glucopyranose, METHYLPHOSPHONIC ACID ESTER GROUP, ... (4 entities in total)
Functional Keywordscholinesterase, organophosphate, serine hydrolase, chemical-warfare, hydrolase
Biological sourceTorpedo californica (Pacific electric ray)
Cellular locationIsoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
Total number of polymer chains1
Total formula weight61257.95
Authors
Millard, C.B.,Silman, I.,Sussman, J.L. (deposition date: 1999-04-21, release date: 1999-11-15, Last modification date: 2023-08-23)
Primary citationMillard, C.B.,Koellner, G.,Ordentlich, A.,Shafferman, A.,Silman, I.,Sussman, J.L.
Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad
J.Am.Chem.Soc., 121:9883-9884, 1999
Cited by
DOI: 10.1021/ja992704i
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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