1ACJ

QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE

Summary for 1ACJ

DescriptorACETYLCHOLINESTERASE, TACRINE (3 entities in total)
Functional Keywordshydrolase(carboxylic esterase)
Biological sourceTorpedo californica (Pacific electric ray)
Cellular locationIsoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein P04058
Total number of polymer chains1
Total molecular weight60990.78
Authors
Sussman, J.L.,Harel, M.,Silman, I. (deposition date: 1993-08-18, release date: 1994-08-31, Last modification date: 2016-06-29)
Primary citation
Harel, M.,Schalk, I.,Ehret-Sabatier, L.,Bouet, F.,Goeldner, M.,Hirth, C.,Axelsen, P.H.,Silman, I.,Sussman, J.L.
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proc.Natl.Acad.Sci.USA, 90:9031-9035, 1993
PubMed: 8415649 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.90.19.9031
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers21.0%6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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