1ACJ

QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001507	biological_process	acetylcholine catabolic process in synaptic cleft
A	0003990	molecular_function	acetylcholinesterase activity
A	0004104	molecular_function	cholinesterase activity
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006581	biological_process	acetylcholine catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019695	biological_process	choline metabolic process
A	0043083	cellular_component	synaptic cleft
A	0045202	cellular_component	synapse
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0098552	cellular_component	side of membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE THA A 999

Chain	Residue
A	HIS440
A	GLY441
A	TRP84
A	GLY118
A	GLU199
A	PHE330
A	TRP432

---

site_id	THA
Number of Residues	4
Details

Chain	Residue
A	SER200
A	HIS440
A	GLU327
A	THA999

---

Functional Information from PROSITE/UniProt

site_id	PS00122
Number of Residues	16
Details	CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpktVtIfGeSAG

Chain	Residue	Details
A	PHE187-GLY202

---

site_id	PS00941
Number of Residues	11
Details	CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIWvP

Chain	Residue	Details
A	GLU92-PRO102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate

Chain	Residue	Details
A	SER200

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	GLU327
A	HIS440

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558

Chain	Residue	Details
A	ASN59

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558, ECO:0000269|PubMed:1678899

Chain	Residue	Details
A	ASN416

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299

Chain	Residue	Details
A	ASN457
A	ASN533

---