1EVE

THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE

Summary for 1EVE

DescriptorACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordsalzheimer's disease, drug, serine hydrolase, alpha/beta hydrolase, neurotransmitter cleavage, catalytic triad, glycosylated protein
Biological sourceTorpedo californica (Pacific electric ray)
Cellular locationIsoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein P04058
Total number of polymer chains1
Total molecular weight62792.61
Authors
Kryger, G.,Silman, I.,Sussman, J.L. (deposition date: 1998-03-04, release date: 1999-01-20, Last modification date: 2020-07-29)
Primary citation
Kryger, G.,Silman, I.,Sussman, J.L.
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Structure Fold.Des., 7:297-307, 1999
PubMed: 10368299 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(99)80040-9
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23050 2.2% 0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
170172
PDB entries from 2020-10-21