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1CFJ

METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE (GB, SARIN)

Summary for 1CFJ
Entry DOI10.2210/pdb1cfj/pdb
DescriptorPROTEIN (ACETYLCHOLINESTERASE), 2-acetamido-2-deoxy-beta-D-glucopyranose, METHYLPHOSPHONIC ACID ESTER GROUP, ... (4 entities in total)
Functional Keywordscholinesterase, organophosphate, serine hydrolase, chemical-warfare, hydrolase
Biological sourceTorpedo californica (Pacific electric ray)
Cellular locationIsoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
Total number of polymer chains1
Total formula weight61274.95
Authors
Millard, C.B.,Silman, I.,Sussman, J.L. (deposition date: 1999-03-19, release date: 1999-06-25, Last modification date: 2023-08-09)
Primary citationMillard, C.B.,Kryger, G.,Ordentlich, A.,Greenblatt, H.M.,Harel, M.,Raves, M.L.,Segall, Y.,Barak, D.,Shafferman, A.,Silman, I.,Sussman, J.L.
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry, 38:7032-7039, 1999
Cited by
PubMed: 10353814
DOI: 10.1021/bi982678l
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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